Download e-book for iPad: Antisense Drug Technology: Principles, Strategies, and by Stanley T. Crooke

By Stanley T. Crooke

widely revised and up-to-date, Antisense Drug expertise: ideas, options, and purposes, moment Edition displays the logarithmic development made long ago 4 years of oligonucleotide-based treatments, and, specifically, antisense therapeutics and examine. examining classes discovered from the medical trials of first new release medicinal drugs, the ebook evaluates the expertise as a complete and gives new instructions and avenues of study and improvement.

Divided into 5 components, the publication starts off with a radical advent to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the aptitude therapeutics of splice switching oligonucleotides. major researchers display the fundamentals of oligonucleotide therapeutics partially by way of delineating medicinal chemistry, pharmacokinetics, and supply routes similar to liposomal formulations for nucleic acid delivery.  half 3 information hybridization established medicinal drugs and considers the dramatic advances represented by means of 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medicines. different chemical sessions of gear and mechanisms of motion are defined partly 4 with extra discussions on enhancing the second one iteration antisense medicinal drugs. the ultimate half delves deeply into healing purposes. Contributing authors research the possibility of antisense medicinal drugs for the relief of cardiovascular illnesses, metabolic ailments, inflammatory illnesses, melanoma, neurological problems, and immune modulation.

Presenting a hugely particular, lucid dialogue of the outstanding advances within the box, Antisense Drug expertise: rules, innovations, and functions, moment Edition offers the platform for researchers to proceed to aggressively pursue the nice chance represented by means of this fascinating technology.

--This textual content refers back to the Hardcover edition.

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Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications by Stanley T. Crooke

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